Natural Factors Stress-Relax®️ Saffron Extract has been clinically shown to help maintain a positive mood, promote restful sleep, and support emotional well-being.* Saffron's crimson threads have impressive mood-improving and stress-relieving qualities that have been supported by clinical research.* Natural Factors Saffron features Affron®️, a 100% pure source of standardized Spanish saffron extract that has been DNA-certified for authenticity and has undergone study in multiple clinical trails.